Summary: Newer concepts in
the pathophysiology and investigations in Autism Spectrum disorders have shown
that many of the medical problems associated with or aggravating autistic
traits, can be overcome to a variable extent, to enhance quality of life of
children with autism, though cure may not be available due to the inborn
multi-genetic problem.
Modern early medical intervention
therapy with regulated diet, avoiding allergens, treating allergies and
infections in gut and appropriate micronutrient support has shown good results. Some children have
inability to transform food Vitamin B12 to Methyl B12, which is needed for neural
activity and subsequently glutathione formation. Most such children are
deficient in MTHFR Enzyme and can be helped in most cases by giving vitamin MB12
subcutaneous injections. Many ASD children genetically lack the capacity for
efficient excretion of heavy metals like mercury. After proper
identification of heavy metal load, these children may be helped by appropriate
chelation therapy.
SPECT Scans of brain can show children who have developed perfusion
defect with anoxic damage in brain due to the multifactorial ASD pathologies. They may be helped where
appropriate with the help of low pressure Hyperbaric air therapy and/or stem cell therapy. The UDAAN Multimode Early
Medical Intervention Therapy Project, aims to study these modern medical advances in more scientific detail, at a cost that many Indian families may
be able to afford. Last updated July 22, 2011
UDAAN Observational Research Project for Early Medical Intervention Therapy for Autism using Dan Protocol based Biochemical guidance, MB12, mHBOT, Stem cells, Chelation, etc supplementing one-to-one Standard Therapies.
The highly successful UDAAN HBOT-Based Multimode Therapy for
Cerebral Palsy in Young Children, with data on 150 children so treated was presented
and highly appreciated at the 7th International Symposium on Hyperbaric
Oxygenation and the Future of Healing, at Irvine, CA, USA, in July 2010 and is available on youtube as a series of seven sequential files marked 1-7 to 7-7
Autism
Our work in Autism has been inspired by the valuable work done in Autism by
workers like Dr. James Neubrander (of MB12 fame) of New Jersey, Dr. Dan Rossignol of University of Virginia, USA, Dr. Paul Harch of New York, late Dr. R A Neubauer of Florida, Dr. Pierre Marois of Canada and many others
UDAAN is now initiating an Indian Research project for Multimode Early Medical Intervention Therapies for young children with
Autism.
Director, FSMHP-UDAAN
C/27-28 Dayanand Colony, Lajpatnagar - 4, New Delhi 110024; INDIA
The interventions planned include
We provide one-to-one daily Standard Therapy (SI, OT, Speech Therapy, Special
Education). Detailed assessment using Internationally
approved scales and thorough medical checkup as per guidelines available from ARI
Website are done to try and identify symptom aggravating genetic defects / inborn errors
of metabolism and allergens. Appropriate dietary guidelines and allergen
avoidance, including examining if a GFCF Diet helps the child. Detecting and
treating all intercurrent infections is essential especially if the child shows sudden change of behavior.
Identify children clinically or by genetic tests to be deficient in MTHFR Enzyme activity and with
high levels of Homocysteine. Give them subcutaneous vitamin MB12 injections as per protocol. Standard Therapy and Dietary guidelines as above
Identify children overloaded with heavy metals, especially mercury by doing appropriate blood tests and DMPS challenge Urinary mercury excretion assessment. Those children proved to be overloaded in toxic heavy metals will be given oral DMPS chelation therapy under stringent medical supervision, regular 3 monthly blood tests, re-assessments, serial video and clinical recording. Full benefits from one 40 session course my need >2 years to develop.
Identify children with brain perfusion defects on SPECT Scan of brain, and give low pressure Hyperbaric Air Therapy to reduce edema, reduce inflammation, promote new blood capillary growth, enhance brain perfusion, and stimulate stem cell activity. This is done under stringent medical supervision, regular blood tests, re-assessments, serial video and clinical recording. The usual time to noticeable improvement in responders (usually > 75%) is 4 to 6 months.
Our pilot experimental studies on the use of Autologous Stem Cell Therapy using the child's own resources, has shown noticeable benefits within 4 weeks, reaching apprecialble levels within 2 to 4 months. However, like mHBOT, the complete benefits may take 2 years to develop. Repeat courses of stem cell may be taken at 6 month+ intervals.
Duration parents with children need to stay at South Delhi:
One week every 3 months, for periodic
assessments, laboratory tests and handing over of necessary drugs, vitamin
and mineral supplements.
Hyperbaric Therapy will require continous stay at Delhi for the duration as it is one session per working day
Special Facilities to be made available to enrolled children:
MB12 subcutaneous injections, 1 ml vials containing thimerosal-free 25 mg/ml MB12. It has been prepared especially for this project by an Indian Pharma
giant, and is currently under legal procedures for regulatory permission.. The drug will be injected using
BD Insulin Syringes with 32 gauge 4 mm needles. We hope to provide the
drug and syringes at raw material price only, which will be a tiny fraction of
International price.
DMPS capsules for Oral/Rectal use, 50 mg each, again at raw material price, will be
made available for this project only, courtesy of the same Pharma giant. We have decided not to use
Intravenous DMPS because of the long term need in small children, where
veins would be at a premium. We have
also decided not to use TD-DMPS, because of its erratic results as per
personal communication with various experts in medical Intervention for Autism, and other authorities met at the
5th Int. Symposium on HBOT and the Recoverable Brain.
Children with Autism have decreased level of Anti-Oxidants like Glutathione, SOD, etc. This enhances inflammatory injury in selected areas of neural tissues
in brain, as seen in SPECT and fMRI Scan of Brain. Because of their (autism affected children) extra vulnerability to Free Radical damage, Dr. Dan Rosignol recommends that they be given HBA at
1.3 ATA using room air (20% Oxygen) only. UDAAN has the necessary Hyperbaric chambers, specifically built to these specifications.
Diet guidelines will be provided by an experienced Dietician
Health care will be looked after by Dr. MS Ray, MBBS, MD (Pediatrics) and
Dr. A Mukherjee, MBBS, MD (Internal Medicine).
During the stay at Delhi for Low Pressure HBA and/or Stem Cell Therapy, special arrangements for Standard Therapy (Special Education,
SI, OT and Speech) have been made at a new dedicated equipped center, providing one-to-one therapy by Special
Educators, Occupational Therapists and Speech Therapists experienced in handling autistic children.
Children staying on at Delhi may avail of continued one-to-one therapy.
Arrangements have been worked out with an Internationally affiliated International Standard Laboratory at Delhi, for carrying out the specialized tests necessary for this project. Because of our mass scale work, we have
managed to get a rebate for these tests.
Accommodation
UDAAN does not have a Guest House.
However, there are many decent, clean, affordable middle class guest houses availoable nearby, which may be availed of by those desirous of short, medium or long term stay.
Special Facility for all Children with Autism in India, even though they may
not be a part of the UDAAN Project
Any child with Autism, whether or not a part of the research project, may avail of the checkup facilities through us at Delhi.
Children who have already started DAN protocol and Standard therapies, may get their low pressure HBA done at UDAAN, subject to
availability of spare time (limited seats). For details and logistics, contact at UDAAN.
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